Prevention of methotrexate-induced nephrotoxicity by concomitantadministration of garlic aqueous extract in rat
نویسندگان
چکیده
منابع مشابه
Prevention of methotrexate-induced nephrotoxicity by concomitant administration of garlic aqueous extract in rat.
BACKGROUND/AIM Methotrexate (MTX) has been widely used for treatment of cancer and rheumatoid arthritis, but its use has been limited by its nephrotoxicity. This study was carried out to determine whether garlic exerts a protective effect against MTX-induced nephrotoxicity. MATERIALS AND METHODS Nephrotoxicity was induced in rats after a single i.p. injection of MTX (20 mg/kg). Garlic extract...
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Gentamicin is an important aminoglycoside antibiotic. However its use is limited to serious and life threatening gram negative infections, because of its high nephrotoxicity potential in patients. There are reports that safranal, the active ingredient of saffron with antioxidant properties, exerts protective effect against ischemic injuries occurred by certain nephrotoxins including gentamicin....
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ژورنال
عنوان ژورنال: TURKISH JOURNAL OF MEDICAL SCIENCES
سال: 2015
ISSN: 1300-0144,1303-6165
DOI: 10.3906/sag-1408-121